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Pre Clinical Studies

  • Âgren, M.S., Almqvist, S., Werthen, M., et al. Cellular model for non-healing chronic venous leg ulcers.

    Poster presented at the 3rd Congress of the World Union of Wound Healing Societies, Toronto, Canada, 2008.

  • Âgren, M.S., Kleinman, H.K. Effect of amelogenins on angiogenesis ex vivo.

    Wound Repair and Regeneration 2007; 14 (3): A74.

  • Âgren, M.S., Werthén, M. The extracellular matrix in wound healing: a closer look at therapeutics for chronic wounds.

    International Journal of Lower Extremity Wounds 2007; 6 (2): 82-97.

  • Grayson, R.E., Yamakoshi, Y., Wood, E.J., Âgren, M.S. The effect of the amelogenin fraction of enamel matrix proteins on fibroblast-mediated collagen matrix reorganization.

    Biomaterials 2006; 27 (15): 2926-33.

  • Rippon, M., Davies, P., White, R. Proposed mode of action of amelogenin as a therapeutic agent in wound healing.

    Poster presented at Wounds UK, Harrogate, United Kingdom, 2006.

  • Thomsen, P., Almqvist, S., Johansson, A., et al. Amelogenin modulates the secretion by dermal fibroblasts of factors involved in wound healing.

    Poster presented at Wounds UK, Harrogate, United Kingdom, 2006.

  • Mirastschijski, U., Konrad, D., Lundberg, E., et al. Effects of a topical enamel matrix derivative on skin wound healing.

    Wound Repair and Regeneration 2004; 12 (1): 100-8.
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How Xelma works

When applied to the wound bed Xelma restores the damaged proteins providing an extracellular matrix protien for cell attachment.
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Pre-clinical data

Pre-clinical studies demonstrated that amelogenin treatment significantly increases fibroblast expression of vascular endothelial growth factor (VEGF), a growth factor that plays an important role in wound healing.
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How to use Xelma

Xelma is indicated for hard-to-heal ulcers - primarliy, venous leg ulcers. Xelma can be used under compression therapy.
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